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About our project
The problem we solve: We invested what we had in the development of our company and our products. Today, through partners, we have production and marketing in India and South Africa. But, we need to license, produce and launch our products in Switzerland and Europe. And for that cost, we need support!
About our solution:
There is no secret. We need to register the products here in Switzerland and launch them on the market. For this, we depend on specialists who work in our company to deal with the bureaucracy and with the creation and marketing structure of the brand. There are two stages: - application for registration; and - placing the brand on the market.
The system of production, distribution, and sale is already structured, the design and packaging are already planned. We are well ahead of our project, but we need financial support in this final stretch!
Progress to
date:
We started our story in March 2017. In this period we have set up contracts with two companies in India and one in South Africa. Both manufacture our products through patent session contracts. These two clients together sell about 150,000 bottles per year. In the period from October 2018 to March 2019, our company sought registration to be authorized to produce, distribute and sell homeopathic products in Switzerland. This authorization was granted on March 15th, 2019. Since then, we are looking for investors for the second stage of this process: the licensing of our products in the European market.
Throughout that time, we developed the packaging, the company brand, the names of our products. We also signed contracts with outsourced producers to reduce manufacturing and distribution costs. So when authorized, our products will go straight from the producer to the shelves of doctors, clinics, and pharmacies.
Also, due to the characteristic of the medical system in Switzerland, our products will be listed in the health system and will have their costs covered by health insurances, not requiring our patients to pay for it.
About Our Team
Creator: Raul de Freitas Buchi
Location: Sankt Gallen (de)
Education: Psychology
Bio: I am graduated in psychology in Brazil, and I worked with it for the lasts 18 years. I have a long experience in managing interpersonal relationships and social environments, with my focus always on mental health over different groups of people involved in this type of health-care: family, health professionals, patients, and social workers. I dedicated myself to the study of various human behavioral patterns and forms (from Foucault to CBT). I worked also in the last five years as add professor in the psychology course in University where I used to teach disciplines related to it. I also got large habitability in project planning and development.
With ample social skills, fluent English, to the colloquial, professional and technical needs, I live now in Switzerland, where I am in the middle of the development of my Deutsch learning. My training and experience are directly linked to the needs of our research. Two years ago, I have found a small company in Zürich with more two partners.
Hospital Affiliation: CEO
Title: Mr.
Advanced Degree(s): MsC
About Team Members
Dorly de Freitas Buchi
Prof. Doctor, MsC and PhD Biography: For over 40 years, I was a professor and researcher at the Federal University in Brazil. During this period I also performed administrative functions and developed various possibilities in the area of electronic microscopy and cell culture. This allowed me to carry out several basic research with highly diluted products. As a result, I found several complexes of high efficiency to the immune system. Two of them, already present in the international market.
Title: Prof. Doctor Advanced Degree(s): MsC and PhD
The use of our products gives the patient a balance in his immunity, both innate and acquired. This modulation of the immune system allows for a greater rapidity in defense against most diseases. Acting as a preventive medication, but also, complementing the conventional treatments that may be being used.
How We Help Physicians
During my academic life, I was “advisor” of many monographs, dissertations and theses about macrophages (MΦ), bone marrow (BM) cells, lymph node lymphocytes (Ly), and tumor cells challenged with single and complex matrices to find the ones that can stimulate the immune system, without side effects – seeking for NEW FORMS OF IMMUNOTHERAPY. These new medicines are biological response modifiers and are produced with homeopathic techniques. All they need to be vigorously shaken to be effective.
These products did not interfere in the cell cycle, did not damage the DNA molecule and did not induce apoptosis. Briefly, they are not toxic, neither mitogenic nor mutagenic. The use of our products gives the patient a balance in his immunity, both innate and acquired. This modulation of the immune system allows for a greater rapidity in defense against most diseases. Acting as a preventive medication, but also, complementing the conventional treatments that may be being used. You can bring this to the patient.
How We Help Hospitals
During my academic life, I was “advisor” of many monographs, dissertations and theses about macrophages (MΦ), bone marrow (BM) cells, lymph node lymphocytes (Ly), and tumor cells challenged with single and complex matrices to find the ones that can stimulate the immune system, without side effects – seeking for NEW FORMS OF IMMUNOTHERAPY. These new medicines are biological response modifiers and are produced with homeopathic techniques. All they need to be vigorously shaken to be effective. These products did not interfere in the cell cycle, did not damage the DNA molecule and did not induce apoptosis. Briefly, they are not toxic, neither mitogenic nor mutagenic. The use of our products gives the patient a balance in his immunity, both innate and acquired. This modulation of the immune system allows for a greater rapidity in defense against most diseases. Acting as a preventive medication, but also, complementing the conventional treatments that may be being used. The benefits of our products can be available in your hospital, and it will help you to give better support to your patients.
How We Help Partners
The registration of the company with SwissMedic, enables BONAIRESWISS A.G. as a producer and exporter of homeopathic products. Also, without the records of the final products, it will not be possible to immediate market the finished products. But the qualification allows the export of RAW MATERIAL (concentrate), the basis of the final products, from Switzerland. Increasing the security of customers and suppliers, bank transparency and added value to the product.
In April 2019, with the registration of the products, and having GMP’s contract with OMIDA, from Schwabe Group, it will be possible for BONAIRESWISS A.G. to produce its Homeopathic Complexes on Swiss soil and sell it in that territory. The expansion into the European and American markets, take hostage of time and investment capacity.
The use of our products gives the patient a balance in his immunity, both innate and acquired. This modulation of the immune system allows for a greater rapidity in defense against most diseases. Acting as a preventive medication, but also, complementing the conventional treatments that may be being used.
Innovation Details
Intellectual Property Summary
The products concern a process to obtain a biological response modifier (BRM), particularly a medication obtained from highly diluted associations of vegetable, mineral and extracts, aiming to make use of its medicinal characteristics, internally and externally, in treatment, prevention, control and elimination of diseases, therapeutic and aesthetic finalities, in human beings.
In the search for new therapies novel drugs and medications are being discovered, developed and tested in laboratories. Highly diluted substances are intended to enhance immune system responses resulting in reduced frequency of various diseases, and often present no risk of serious side-effects due to its low toxicity. It was developed and tested several highly diluted tinctures and it was described the biological activity of M1, M2, and M8. Cytotoxicity, cytokines released and NF- ?B activation were determined after in vitro treatment. Cell viability, oxidative response, lipid peroxidation, bone marrow, and lymph node cells immunophenotyping were accessed after in vivo treatment. None of the tested highly diluted tinctures were cytotoxic. All compounds enhanced the innate immunity, but M1 also augmented acquired immunity and M2 diminished B lymphocytes, responsible for acquired immunity.
Biological assays are intended to understand better what happens within a cell when a molecule interacts with its target. In order to determine the efficacy and safety of new drugs, there is a clear move within the pharmaceutical industry towards an increased emphasis on cell-based assays. Well-structured methodological studies are useful to understand how highly diluted tinctures work.
It was certified high quality, physicochemical composition, and endotoxin-free conditions of its matrices. Dilution procedures have followed the standard methodology described at the Homeopathic Pharmacopoeia. In brief, starting from a whole extract (MT) or initial decimal dilutions (dH or x) of several tinctures, the highly diluted tinctures were obtained by serial decimal dilutions in distilled water (1 part of tincture to 9 parts of water – v/v). In between each dilution, the solution was vigorously manual shaken (by hand) with 100 strong vertical strokes against a soft pad. The resulting aqueous solution is colorless and odorless and contains less 0.1% alcohol. These were stored in the dark at room temperature.
These highly diluted tinctures were shown to modulate immune responses. After using different products and analyzing the different results carefully, we arrived at three complexes produced with homeopathic techniques, coded as M1, M2, and M8. The results obtained using these products were surprising and some were even published in scientific journals with good impact. These combinations of highly diluted tinctures could be used as therapeutic interventions in disorders where the immune system is compromised.
It was used as the most actual and diverse methodology, with several controls: Confocal, Histochemistry, Electron Microscopes, Flow Cytometer, Slide Scanner, Matrigel matrix invasion, ImageJ software, etc. It was demonstrated that these medicines prevent lung and subcutaneous melanoma growth, decreased angiogenesis inside tumor (p<0.01); decreased some extracellular matrix molecules, as Perlecan and Hyaluronic Acid, decreasing metastasis (in Transwell plates, p<0.01); activated macrophages, that can activate others in immune system and other structures as endothelial cells and fibroblasts; modulated cytokines like TNFα, IFNγ, IL10; increased not only the differentiation to NK cells (inflow cytometer p<0.001) but also the cytotoxicity of NK cells (p<0.05); reactive oxygen species (ROS) and nitric oxide (NO) production was modulated.
Therefore, M1, M2, and M8 are homeopathic complex medicines (HCM) with immunomodulatory properties, without toxicity nor mutagenic effects. This homeopathic immunotherapy can kindly restore the immune system to recognize tumor cells and these highly diluted tinctures could be used as therapeutic interventions in disorders where the immune system is compromised.
Regulatory Status
We are requesting the license to Swiss and European market with SwissMedic. As a homeopathic product, it requires only a formal notification to the FDA, if it one day is needed. But, now it is not our aim.
How we will use the funds raised
Responsible Pharmaceitical cost
$15 000,00
License and registration
$5 000,00
First bench
$10 000,00
Marketing
$100 000,00
Website development
$10 000,00
Company workers
$60 000,00
Thank You
The proposal of Bonaireswiss is to bring for the first time to the market highly diluted products grounded on basic research and that have proven to act as immunotherapy agents.
Once again homeopathy surprises the scientific world with wonderful results. Published in the Spandidos Publication Magazine, the article by Brazilian scientists shows how homeopathic complexes have the ability to positively modify the functioning of the immune system.
https://bonaireswiss.ch/scientific-revolutions-in-homeopathy/
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I am graduated in psychology in Brazil, and I worked with it for the lasts 18 years. I have a long experience in managing interpersonal relationships and s...
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